Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism‐Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu (Adv. Sci. 13/2023)

Mesenchymal Stromal Cell (MSC) Ferroptosis As reported in article number 2206439 by Ling Tao, Fuyang Zhang, and co-workers, MSCs are seriously damaged the reactive oxygen species (ROS) after injection into injured liver milieu rapidly deplete due to ferroptosis driven ROS-induced lipid peroxidation, like devouring fire forest threatening entered firefighters. Strategies reducing ferroptosis, such as incorporating inhibitors or overexpressing BCAT1, protect implanted from ROS-irritated hence improving MSC retention therapeutic effectiveness, similar firefighters shielded firefighting clothing equipment.